Strasbourg is the capital and principal city of the Alsace region in north-eastern France and is the official seat of the European Parliament. Located close to the border with Germany, it is the capital of the Bas-Rhin department. In 2006, the city proper had 272,975 inhabitants and its urban community 467,375 inhabitants. With 638,670 inhabitants in 2006, Strasbourg's metropolitan area ("aire urbaine") (only the part of the metropolitan area on French territory) is the ninth largest in France. The transnational Eurodistrict Strasbourg-Ortenau has a population of 884,988 inhabitants.

Basel is one of the important cities of Switzerland. One of Switzerland's underrated tourist destinations, Basel has a beautiful medieval old town centre, a vibrant Carnival, and several world class art museums built by architects like Renzo Piano, Mario Botta and Herzog & De Meuron. Basel is also rich in architecture old and new, with a Romanesque Münster (cathedral), a Renaissance Rathaus (town hall), and various examples of high quality contemporary architecture, including more buildings by Herzog & De Meuron, Richard Meier, Diener & Diener, and various others. Located in the Dreiländereck (three countries' corner), Basel is a gateway to the Swiss Jura mountains and nearby cities of Zürich and Lucerne, as well as the neighbouring French region of Alsace and the German Black Forest.