Messina is a harbor city in northeast Sicily, Italy. It is the capital of the Italian Metropolitan City of Messina, and has close ties with Reggio Calabria. The city's main resources are its seaports (commercial and military shipyards), cruise tourism, commerce, and agriculture (wine production and cultivating lemons, oranges, mandarin oranges, and olives). The city has been a Roman Catholic Archdiocese and Archimandrite seat since 1548 and is home to a locally important international fair. The city has the University of Messina, founded in 1548 by Ignatius of Loyola. Messina has a light rail system, Tranvia di Messina, that was opened on 3 April 2003. This line is 7.7 kilometres (4.8 mi) and links the city's central railway station with the city centre and harbour. The city is home to a significant Greek-speaking minority, rooted in its history and officially recognised.

Livorno is an Italian port city on the Ligurian Sea, on the western coast of Tuscany, Italy. Traditionally been known in English as Leghorn, it's known for its seafood, Renaissance-era fortifications and modern harbor with a cruise ship port.

Piraeus is a city in the periphery of Attica,  Greece and within the Athens urban area, located 12 km southwest of its center and upon the Saronic Gulf. According to the 2001 census, Piraeus has a population of 175,697 people within its administrative limits, making it the third largest municipality in Greece and the second within the Greek capital following the municipality of Athens. The Piraeus urban area extends beyond the administrative city limits to the suburban municipalities, with a total population of 466,065. 

Civitavecchia is a town and comune of the Metropolitan City of Rome in the central Italian region of Lazio. A sea port on the Tyrrhenian Sea, the name ''Civitavecchia'' means "ancient town". The modern city was built over a pre-existing Etruscan settlement. The massive Forte Michelangelo was first commissioned from Donato Bramante by Pope Julius II, to defend the port of Rome. The upper part of the "maschio" tower, however, was designed by Michelangelo, whose name is generally applied to the fortress. North of the city at Ficoncella are the Terme Taurine baths frequented by Romans and still popular with the Civitavecchiesi. The modern name stems from the common fig plants among the various pools. And also next to the town is the location of the cruise ship docks. All major cruise lines start and end their cruises at this location, and others stop for shore excursion days that allow guests to see Rome and Vatican sights, which are ninety minutes away.